Oral-M®採集癌前病變處或模稜兩可處之口腔黏膜上皮細胞，定性檢測口腔上皮細胞中ZNF582基因之甲基化程度，可輔助醫師目視診斷口腔癌發生的風險，達到早期發現早期治療目標。
- 經醫師篩檢發現口腔黏膜異常
- 有抽菸、喝酒或嚼檳榔習慣
- 口腔慢性發炎兩週以上未癒合
- 口腔內有白斑或腫塊
- 自覺口腔黏膜有異狀
- 未有菸酒檳榔史，想瞭解口腔健康狀況
檢測優勢
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檢測流程
檢測優勢
檢測流程
臨床實證
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Cheng SJ, Chang CF, Lee JJ, et al. Hypermethylated ZNF582 and PAX1 are effective biomarkers for detection of oral dysplasia and oral cancer. Oral Oncol. 2016;62:34-43. doi:10.1016/j.oraloncology.2016.09.007
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Cheng SJ, Chang CF, Ko HH, et al. Hypermethylated ZNF582 and PAX1 genes in oral scrapings collected from cancer-adjacent normal oral mucosal sites are associated with aggressive progression and poor prognosis of oral cancer. Oral Oncol. 2017;75:169-177. doi:10.1016/j.oraloncology.2017.11.013
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Cheng SJ, Chang CF, Ko HH, et al. Hypermethylated ZNF582 and PAX1 genes in mouth rinse samples as biomarkers for oral dysplasia and oral cancer detection. Head Neck. 2018;40(2):355-368. doi:10.1002/hed.24958
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Yang CC, Wu CH, Chang CF, Hung CP, Sy M, et al. (2018) DNA methylation confers clinical potential to predict the oral cancer prognosis. Clin Res Trials 4: DOI: 10.15761/CRT.1000232.
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Sun R, Juan YC, Su YF, et al. Hypermethylated PAX1 and ZNF582 genes in the tissue sample are associated with aggressive progression of oral squamous cell carcinoma. J Oral Pathol Med. 2020;49(8):751-760. doi:10.1111/jop.13035
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Juan YC, Su YF, Bai CH, Fan YC, Kuo TT, Ko HH, Peng HH, Chiang CP, Fwu CW, Cheng SJ. ZNF582 hypermethylation as a prognostic biomarker for malignant transformation of oral lesions. Oral Dis. 2021 Jun 19. doi: 10.1111/odi.13946. PMID: 34145953.
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Su YF, Chen YJ, Tsai FT, Li WC, Hsu ML, Wang DH, Yang CC. Current Insights into Oral Cancer Diagnostics. Diagnostics (Basel). 2021 Jul 16;11(7):1287.
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Chiu YW, Su YF, Yang CC, et al. Is OLP potentially malignant? Aclue from ZNF582 methylation. Oral Dis. 2021 Dec 30. doi: 10.1111/odi.14120. Online ahead of print.